The Burgess Lab studies how metabolic flux is regulated by molecular physiology, altered by disease, pharmacology or targeted genetic interventions. We focus on pathways of oxidative and biosynthetic metabolism in the context of obesity, insulin resistance and diabetes. Over the years, our work has encompassed metabolism in liver, heart, muscle, adipose and β-cell. Disentangling the molecular metabolism of these systems requires expertise in chemistry, instrumental analysis, molecular metabolism, physiology and translational approaches. Specifically, we have a large effort in the use of NMR spectroscopy, mass spectrometry, isotopomer analysis, modeling and applications of these technologies in genetically-manipulated model systems as well as in human subjects. We seek to understand how metabolism is controlled and how defects in metabolism may influence the outcome of disease. Dr. Burgess also works with Drs. Sherry and Malloy in developing the training component. He is highly qualified by his experience in teaching, research and administration to lead the project.
Members of the National Center for In Vivo Metabolism