The primary interest of the Jin Lab is metabolic dysregulation in the liver and skeletal muscles. We use stable isotopes (13C and 2H) and high resolution NMR to study intermediary metabolism in animal models and human subjects with problems in obesity, metabolic syndrome, fatty liver, hepatotoxicity, or liver cancer. We are interested in isotope labeling patterns in plasma metabolites that reflect hepatic biochemical processes with the use of stable isotopes. Dr. Jin introduced 13C-labeled glycerol to estimate multiple metabolic processes in the liver, and the method has been successfully applied to patients with liver disease or other problems.
Members of the National Center for In Vivo Metabolism