Center for In Vivo Metabolism UTSW
Annual Symposium 2018

The 25th Annual Symposium was titled Imaging Metabolism in Brain Disease and was held on January 30st to February 1st 2018 on Campus at UTSouthwestern Medical Center. The Symposium covered areas like Inborn Errors in Brain Metabolism as well as Brain Cancer, Concussion and Neurodegeneration.

This year Annual Symposium had a record breaking 155 registered attendees and more than 15 speakers from UTSW and institutions nationwide. A poster competition for postdocs and students was also introduced, which was a tremendous success with more than 30 submitted poster abstracts. We would like to congratulate our poster prize winners Ayse Ercan and Divya Bezwada and Runner-ups Cherise R. Chin Fatt and Zhongxu An.

Target Audience

This Symposium is intended for physicians, scientists and students with an interest in metabolic imaging of brain disease.

Purpose and Content

Abnormalities in metabolism are associated with many brain diseases. Despite advances in clinical diagnostic tools, limitations on current methods to characterize and visualize changes in brain functions and metabolism remain a significant barrier to understanding common brain disorders. The Symposium was designed to advance our understanding of the role of metabolism in brain diseases and to explore new methods to image metabolic pathways in human patients. Basic concepts in metabolism as well as MRI, MR spectroscopy and hyperpolarized 13C MRI will be reviewed. Recent developments in imaging of brain diseases will be presented by internationally-recognized experts and by UT Southwestern faculty. Demonstrations of sample preparation and operation of hyperpolarized 13C MRI set-up will be available. This Symposium is supported by the National Institute of Heath - National Institute of Biomedical Imaging and Bioengineering (NIH-NIBIB: EB015908) and by the O’Donnell Brain Institute at the University of Texas Southwestern Medical Center.

Educational Objectives

Metabolic imaging plays important roles in the diagnosis and treatment of brain diseases. Upon completion of the Symposium, attendees should be able to:

  • Describe basic principles of intermediary metabolism in the brain.
  • Identify high-impact brain disorders that are caused by primary defects in metabolism
  • Describe fundamental principles and applications of CEST MRI.
  • Describe the physiologic basis for functional MRI of the brain.
  • Describe the potential role of hyperpolarized 13C MR in imaging compared to current clinical tools.

Wednesday, January 30, 2018


Time Title Speaker
7:30 am Breakfast & Registration  
  Morning Sesssion 1 Moderator: Lloyd Lumata, PhD
University of Texas at Dallas
8:30 am Replacing Radiation in Metabolic Research Craig Malloy, MD
UT Southwestern Medical Center
9:00 am Hyperpolarized 13C: Basic Principles Jae Mo Park, PhD
UT Southwestern Medical Center
9:30 am Hyperpolarized 13C MRI: Early Clinical Applications John Kurhanewicz, PhD
UC San Francisco
10:00 am Break  
  Morning Sesssion 2 Moderator: Charlie Khemtong, PhD
UT Southwestern Medical Center
10:30 am Water: The Best Biomarker of Metabolism! Dean Sherry, PhD
UT Southwestern Medical Center
11:00 am CEST: Pulse Sequences and Chemical Specificity Elena Vinogradov, PhD
UT Southwestern Medical Center
11:30 am Cancer Prognosis by CEST Masaya Takahashi, PhD
UT Southwestern Medical Center
12:00 pm Lunch  
  Facility Tour and Demos  
1:00 pm Convene in NG, Tour Group Assignments  
 
1:15pm
1:45pm
2:15pm
Spinlab/Clinical MRI
Group A
Group B
Group C
Crystal Harrison, PhD; Jian-xiong Wang, PhD
 
1:15pm
1:45pm
2:15pm
HyperSense/SwissSense
Group B
Group C
Group A
Gaurav Sharma, PhD
 
1:15pm
1:45pm
2:15pm
Fluid Path Preparation
Group C
Group A
Group B
Jeff Liticker, PharmD; Jeannie Baxter, RN
  Afternoon Session Moderator: Dean Sherry, PhD
UT Southwestern Medical Center
3:00 pm The Challenge of the Brain: Metabolism in Many Compartments Doug Rothman, PhD
Yale University
3:45 pm Metabolic Basis of fMRI Richard Buxton, PhD
UC San Diego
4:30 pm Reception and Posters  

Thursday, February 1, 2018


Time Title Speaker
7:30 am Breakfast & Registration  
  Morning Sesssion 1
Inborn Errors in Metabolism
Moderator: Juan Pascual, PhD
UT Southwestern Medical Center
8:30 am Biochemical Basis of Neurodevelopmental Disorders Andrea Gropman, MD
Children's National Health System
9:15 am Integration of Clinical, Genetic and Imaging Data for Evaluation of Inborn Erorrs Ralph Deberardinis, MD, PhD
UT Southwestern Medical Center
10:00 am Break  
  Morning Sesssion 2
Brain Cancer
Moderator: Bruce Mickey, MD
UT Southwestern Medical Center
10:30 am MR spectroscopy studies of brain cancer Sabrina Ronen, PhD
UC San Francisco
11:15 am In Vivo Metabolomics of Brain Cancer Changho Choi, PhD
UT Southwestern Medical Center
12:00 pm Lunch  
  Afternoon Sesssion 1
Imaging after Concussion
Moderator: Christopher Madden, MD
UT Southwestern Medical Center
1:00 pm MEG and MRI in TBI Joseph Maldjian, MD
UT Southwester Medical Center
1:45 pm Brain Metabolism after Concussion Brenda Bartnik-Olson, PhD
Loma Linda University
2:30 pm Break  
  Afternoon Sesssion 2
Neurodegeneration
Moderator: Mark Goldberg, MD
UT Southwestern Medical Center
3:00 pm MRI and PET for Evaluation of Age Related Cognitive Decline Prashanthi Vemury, PhD
Mayo Clinic
3:45 pm MR Spectroscopy of Neuropsychiatric Disorders Peter Barker, DPhil
Johns Hopkins University
4:30 pm Poster Award, Discussion and Adjourn Craig Malloy, MD
UT Southwestern Medical Center